Correlation between CENP-F mRNA expression and lymph node metastasis in oral squamous cell carcinomas

Hideo SHIGEISHI; Kuniko MIZUTA; Koichiro HIGASHIKAWA; Hiroshi SHIMASUE; Koji OHTA; Shigehiro ONO; Masaru SUGIYAMA; Nobuyuki KAMATA

doi:10.5794/jjoms.51.77

Hideo SHIGEISHI, Kuniko MIZUTA, Koichiro HIGASHIKAWA, Hiroshi SHIMASUE, Koji OHTA, Shigehiro ONO, Masaru SUGIYAMA, Nobuyuki KAMATA

Author information

Hideo SHIGEISHI
Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Kuniko MIZUTA
Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Koichiro HIGASHIKAWA
Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Hiroshi SHIMASUE
Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Koji OHTA
Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Shigehiro ONO
Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Masaru SUGIYAMA
Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Nobuyuki KAMATA
Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University

Keywords: CENP-F, OSCC, lymph node metastasis

JOURNAL FREE ACCESS

2005 Volume 51 Issue 2 Pages 77-81

DOI https://doi.org/10.5794/jjoms.51.77

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Abstract

Expression levels of CENP-F mRNA were investigated in 45 surgically resected oral squamous cell carcinomas (OSCC) and 10 samples of normal gingiva, using real time reverse-transcriptase polymerase chain reaction (RT PCR). The relations between CENP-F mRNA and clinicopathologic variables were studied. The mean expression level of CENP-F mRNA was higher in OSCC tissues than in normal gingiva. There was a significant correlation between the expression level of CENP-F mRNA and lymph node metastasis in the cases of OSCC (p=0.024). These results suggest that OSCC with a high expression level of CENP-F mRNA has high metastatic potential.

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