A case of Laugier-Hunziker-Baran syndrome

Abstract

Laugier-Hunziker-Baran syndrome is characterized by multiple and melanin pigmentation of the lips, oral mucosa, and fingers. There is no risk of development of oral malignancies or malignant melanoma. However, it is important that Laugier-Hunziker-Baran syndrome is diagnosed correctly to rule out other differential diagnoses (i.e. Peutz-Jeghers syndrome, Addison disease, and Albright syndrome).
A 69-year-old man presented with multiple pigmented spots of the mouth and lips; these spots appeared 3 yearspreviously.
His right fingers had brownish spots 2-3 mm in diameter. Similar spots were present on the buccal mucosa, lips, palate, and gingiva.
The patient had no history of gastrointestinal disorders or generalized skin disorders. A biopsy specimen takenfrom a site of the lower lip with melanotic pigmentation showed increased pigmentation of the basal cell layer ofthe epithelium. No malignant features were noted in the specimen.