Abstract
Case: A 60s woman visited to our hospital with symptoms of pain on right maxillary gingiva. There is no redness or swelling on the right maxillary gingiva or palatal mucosa, but allodynia was observed. Computed tomography revealed the right maxilla was rough and no sequestration. The patient had performed heavy ion radiotherapy for right nasal and sinus malignant melanoma （T3N0M0） 10 years ago. There were no findings local recurrence and metastasis of the tumor and radiation osteomyelitis. Thus, we diagnosed neuropathic pain as a late adverse event by ion radiotherapy. Prescription of pregabalin reduced her pain in the maxilla mucosa.
Discussion: There are few reports of late adverse events of ion radiotherapy for nasal, sinus, and head and neck tumors. Peripheral neuropathy may occur as a late adverse event for ion radiotherapy in the patient with nasal, sinus, and head and neck tumors. In this case, protracted neuropathic pain was attenuated by prescription of pregabalin.
Conclusion: We experienced a case with cancer survivorship who has neuropathic pain as a late adverse event of ion radiotherapy. It was managed by analgesic pharmacotherapy.
