Abstract
Purpose: Treatments for classical trigeminal neuralgia include drug therapy, nerve block therapy, and surgical treatment. There is no doubt that carbamazepine is the first choice for medication treatment. However, carbamazepine is also known as a drug with a high incidence of side effects. On the other hand, drug therapy for the pathology of neuropathic pain is challenging and stable effects have not been obtained. Recently, it has been reported that botulinum toxin treatment is effective for intractable trigeminal neuralgia and neuropathic pain. A meta-analysis of botulinum toxin on trigeminal neuralgia and neuropathic pain confirmed its analgesic effect, which was an essential index of the study. On the other hand, since the units used （25-100units） differ for each study, various indicators such as the number of seizures are used for each study. It is positioned botulinum toxin should be used as an additional therapy for carbamazepine-resistant patients. In this review, we describe the efficacy of botulinum toxin for trigeminal neuralgia and neuropathic pain based on clinical studies.
