The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
Short Communications
Local Anti-inflammatory Activity and Systemic Side Effects of NM-135, a New Prodrug Glucocorticoid, in an Experimental Inflammatory Rat Model
Takayuki IshiiNobuyuki KibushiTakashi NakajimaTae KakutaNoriko TanakaChiaki SatoKei SugaiIsao Kijima-SudaHirofumi KaiTakeshi Miyata
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1998 Volume 78 Issue 4 Pages 505-509


The local anti-inflammatory activity and systemic side effects of NM-135 (6α, 9-difluoro-11β-hydroxy-16α-methyl-21[[2, 3, 4, 6-tetrakis-O-(4-methylbenzoyl)-β-D-glucopyranosyl]oxy]-pregna-1, 4-diene-3, 20-dione) in croton oil-induced granuloma pouches and ear edema in rats were studied. The local anti-inflammatory activity of NM-135 was stronger than that of betamethasone 17-valerate (BV). As to systemic side effects, BV and diflucortolon valerate (DFV) caused thymolysis at the doses required for the anti-inflammatory activity. In contrast, no clear systemic side effect was observed in rats administered NM-135 at the dose producing the anti-inflammatory activity. These results suggest that NM-135 is a drug exhibiting a high degree of dissociation between the local anti-inflammatory activity and systemic side effects.

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© The Japanese Pharmacological Society 1998
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