IPD-1151T (Suplatast Tosilate) Inhibits Interleukin (IL)-13 Release but Not IL-4 Release From Basophils

Michitaka Shichijo; Yasuo Shimizu; Kenju Hiramatsu; Michinori Togawa; Naoki Inagaki; Kenzo Takagi; Hiroichi Nagai

doi:10.1254/jjp.79.501

Short Communications

IPD-1151T (Suplatast Tosilate) Inhibits Interleukin (IL)-13 Release but Not IL-4 Release From Basophils

Michitaka Shichijo, Yasuo Shimizu, Kenju Hiramatsu, Michinori Togawa, Naoki Inagaki, Kenzo Takagi, Hiroichi Nagai

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Keywords: IPD-1151T (suplatast tosilate), Basophil, Interleukin-13

JOURNAL FREE ACCESS

1999 Volume 79 Issue 4 Pages 501-504

DOI https://doi.org/10.1254/jjp.79.501

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Abstract

The effect of suplatast tosilate (IPD-1151T), which is known to suppress interleukin (IL)-4 release from T cells, on the release of IL-4 and IL-13 from human peripheral basophils was investigated. Basophils were obtained from 16 mite-sensitive atopic asthmatic patients. IPD-1151T clearly inhibited the antigen-induced release of IL-13 but not IL-4. These results suggest that IPD-1151T possesses different activity for the regulation of cytokine release in basophils and T cells.

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