The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
Short Communications
Effects of Toluene on Regulation of Adenylyl Cyclase by Stimulation of G-Protein-Coupled Receptors Expressed in CHO Cells
Hirofumi TsugaRui-Sheng WangTakeshi Honma
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1999 Volume 81 Issue 3 Pages 305-308

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Abstract

We determined the effects of toluene exposure on activation or inhibition of adenylyl cyclase by stimulating human β2-adrenergic receptors (β2-AR) and muscarinic acetylcholine receptor (mAChR) m2 subtypes, respectively, expressed in CHO cells. The formation of cAMP via β2-AR stimulation was slightly but not significantly facilitated in the presence of 3.7 μM toluene. On the other hand, the inhibition of adenylyl cyclase by 10 μM of carbamylcholine stimulation of mAChR m2 subtypes was attenuated in the presence of toluene. These results strongly suggest that toluene affects activation of Gi rather than Gs.

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© The Japanese Pharmacological Society 1999
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