The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
Short Communications
Decrease of Sexual Receptivity by Prolylendopeptidase Inhibitor in Female Rats
Izumi OosukaYoshiaki TanakaNaoyoshi MiuraKorehito Yamanouchi
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2000 Volume 83 Issue 1 Pages 82-85

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Abstract
The effects of a prolylendopeptidase inhibitor, 1−[3−(2−indanylanylacetyl)−L−thioprolyl]pyrrolidine(Z−321), on lordosis behavior were investigated in estrogen and progestrone−treated ovariectomized rats.Females were orally administered 100, 200 or 300 mg/kg Z−321 or the vehicle(control).The mean lordosis quotient in the rats given 300 mg/kg Z−321 was lower than that in control group, but that in rats given 100 or 200 mg/kg Z−321 was not lower.Thus, Z−321 suppressed lordosis in estrogen and progesterone−treated ovariectomized rats.Peptide neurotransmitters, especially those containing proline, are though to be involved in the inhibitory mechanisms for lordosis behavior.
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© The Japanese Pharmacological Society 2000
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