Acceleration by KW-5092 of Intestinal Motility Associated With Acetylcholine Release In Vivo

Abstract

Effect of KW−5092({1−[2−[[[5−(piperidinomethyl)−2−furanyl]methyl]amino]ethyl]−2−imidazolidinylidene}propanedinitrile fumarate)on intestinal motility and release of endogenous acetylcholine(ACh)were measured simultaneously in the small intestine of anesthetized dog using the in vivo microdialysis method.Intraarterial and intravenous administrations of KW−5092 accelerated the intestinal motility and increased dialysate ACh concentrations.These KW−5092−induced responses paralleled the increase in blood concentration of KW−5092.Thus, the acceleration of intestinal motility by KW−5092 was found in vivo to be associated with an increase in ACh release from the intestinal cholinergic neurons.