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The Japanese Journal of Pharmacology
Vol. 83 (2000) No. 3 P 277-278

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http://doi.org/10.1254/jjp.83.277

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Pharmacological blockade of Ca2+−independent phospholipase A2(PLA2)is reported to disintegrate hippocampal synaptic plasticity, which is thought to be the cellular mechanism underlying learning and memory.Therefore, we investigated the effect of the Ca2+−independent PLA2 inhibitor bromoenol lactone(BEL)on spontaneous alteration behaviors of mice.When 3 nmol BEL was intracerebroventricularly injected 30 min prior to the test, the mice showed a poor alternation ratio, compared with control animals.The data suggest that Ca2+−independent PLA2 activity is required for spatial memory.

Copyright © The Japanese Pharmacological Society 2000

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