Entrainment Function in the Suprachiasmatic Nucleus of Streptozotocin-Induced Diabetic Rats

Abstract

The term for re−entrainment to a new light−dark cycle in streptozotocin(STZ)−induced diabetic rats was significantly longer than that in control rats.In STZ−induced diabetic rats, the same level of phase delay in the suprachiasmatic nucleus neuronal firing rhythm was observed in control rats after glutamate application.Therefore, 5−HT function in the hypothalamus is thought to be decreased in STZ−induced diabetic rats.These results suggest that postsynaptic neuronal function is still maintained in the suprachiasmatic nucleus of STZ−induced diabetic rats.Therefore, 5−HT mechanisms may play an important role in the maintenance of this function.