Effect of Intracerebroventricular Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Scopolamine-Induced Amnesic Mice

Abstract

The effect of intracerebroventricularly administered soybean lecithin transphosphatidylated phosphatidylserine(SB−tPS)on memory impairment was evaluated by a passive avoidance task.SB−tPS significantly prolonged the step−through latency induced by scopolamine treatment as in our previous report where SB−tPS was orally administered.The same doses of soybean phosphatidylcholine were ineffective.This result indicates that SB−tPS can act on the brain without any peripheral modification.