The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
Short Communications
Effects of HSP-117, a Novel Tachykinin NK1-Receptor Antagonist, on Cisplatin-Induced Pica as a New Evaluation of Delayed Emesis in Rats
Masakazu SaekiMichinori SakaiRyo SaitoHisahiko KubotaHideto AriumiYukio TakanoAtsushi YamatodaniHiro-o Kamiya
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2001 Volume 86 Issue 3 Pages 359-362


The effects of a novel tachykinin NK1-receptor antagonist HSP-117 {(2S,3S)-3-[(5-isopropyl-2,3-dihydrobenzofuran-7-yl)methyl]amino-2-phenylpiperidine dihydrochloride} on cisplatin-induced pica, i.e., the eating of nonnutritive substances such as kaolin were examined in rats. HSP-117 inhibited kaolin intake in a dose-dependent manner for 2 days. The 5-HT3-receptor antagonist ondansetron inhibited only on the first day, but not on the second day. These results indicate that the cisplatin-induced kaolin intake on the first day is related to both 5-HT3- and NK1 receptors, while only the NK1 receptor is involved on the second day. Thus, cisplatin-induced continuous pica in rats represents a useful model of not only acute but also delayed emesis.

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© The Japanese Pharmacological Society 2001
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