Age-Related Decrease in Calcitonin Gene-Related Peptide mRNA in the Dorsal Root Ganglia of Spontaneously Hypertensive Rats

Naka Yamaga; Hiromu Kawasaki; Keiichi Inaizumi; Miho Shimizu; Arisa Nakamura; Yuji Kurosaki

doi:10.1254/jjp.86.448

Short Communications

Age-Related Decrease in Calcitonin Gene-Related Peptide mRNA in the Dorsal Root Ganglia of Spontaneously Hypertensive Rats

Naka Yamaga, Hiromu Kawasaki, Keiichi Inaizumi, Miho Shimizu, Arisa Nakamura, Yuji Kurosaki

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Keywords: Calcitonin gene-related peptide (CGRP) mRNA, Mesenteric arterial CGRP content, Spontaneously hypertensive rat

JOURNAL FREE ACCESS

2001 Volume 86 Issue 4 Pages 448-450

DOI https://doi.org/10.1254/jjp.86.448

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Abstract

Age-related changes in levels of calcitonin gene-related peptide (CGRP) mRNA of the dorsal root ganglia was studied in 8-, 12- and 15-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto rats (WKY). CGRP mRNA levels in SHR but not in WKY decreased with age. The contents of CGRP-like immunoreactivities in the atrium and mesenteric artery of 15-week-old SHR were greater than those in age-matched WKY. These results suggest that the outflow of CGRP-containing nerves from the spinal cord and CGRP release from CGRP nerve terminals decreases in SHR.

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