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The Japanese Journal of Pharmacology
Vol. 88 (2002) No. 3 P 351-354

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http://doi.org/10.1254/jjp.88.351

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In the present study, we examined whether cholinergic agonists would elicit an itch-associated response in mice. When mice were given an intradermal injection of carbachol (1 – 10 nmol) or bethanechol (0.3 – 100 nmol) into the rostral back, they showed the dose-dependent increase of scratching. Nicotine (1 – 10 nmol) showed no effect. Pretreatment with naloxone, but not with terfenadine, significantly suppressed the carbachol-induced scratching. When intradermally co-injected with carbachol, atropine and 4-DAMP but neither methoctramine nor pancuronium significantly inhibited the carbachol-induced scratching. Muscarinic agonists are suggested to produce itch through activation of M3 muscarinic receptors in the skin.

Copyright © The Japanese Pharmacological Society 2002

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