Hyperpolarization-Activated Current Ih in Nucleus of Solitary Tract Neurons: Regional Difference in Serotonergic Modulation

Yuki Iwahori; Yuji Ikegaya; Norio Matsuki

doi:10.1254/jjp.88.459

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Hyperpolarization-Activated Current I_h in Nucleus of Solitary Tract Neurons: Regional Difference in Serotonergic Modulation

Yuki Iwahori, Yuji Ikegaya, Norio Matsuki

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Keywords: Nucleus of solitary tract, Hyperpolarization-activated current, Serotonin

JOURNAL FREE ACCESS

2002 Volume 88 Issue 4 Pages 459-462

DOI https://doi.org/10.1254/jjp.88.459

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Abstract

The nucleus of solitary tract (NTS) contains diverse neural circuits responsible for basic vital functions. We examined the effect of serotonin (5-HT) on hyperpolarization-activated current (I_h) in neurons acutely isolated from caudal, medial and rostral parts of the NTS. Caudal and medial NTS neurons showed a large amplitude of I_h compared with rostral neurons. In these neurons, perfusion with 5-HT potentiated I_h amplitude in a concentration-dependent manner. The effect of 5-HT was blocked by NAN-190, a 5-HT_1A receptor antagonist. Thus, 5-HT_1A receptors may regulate I_h channel activity in caudal and medial NTS neurons.

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