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The Japanese Journal of Pharmacology
Vol. 89 (2002) No. 4 P 422-425

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http://doi.org/10.1254/jjp.89.422

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To investigate the role of catecholamine release in emesis, we examined the effects of pretreatment with 6-hydroxydopamine (6-OH-DA) administered into the area postrema in morphine-induced emesis in ferrets. In the 6-OH-DA pre-treated animals, the latency to the first emetic response induced by morphine hydrochloride (1.0 mg/kg, s.c.) was significantly prolonged and the number of retches and emetic episodes was markedly reduced. In the medulla oblongata, the levels of dopamine and homovanilic acid were reduced by 6-OH-DA pretreatment. These results suggest that catecholamine release in the medulla oblongata, mainly dopamine release, may play an important role in morphine-induced emesis in ferrets.

Copyright © The Japanese Pharmacological Society 2002

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