The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
Short Communications
PAC1 Receptor-Mediated Relaxation of Longitudinal Muscle of the Mouse Proximal Colon
Kazunori MukaiYuji SatohAkikazu FujitaTadayoshi TakeuchiNorihito ShintaniHitoshi HashimotoAkemichi BabaFumiaki Hata
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2002 Volume 90 Issue 1 Pages 97-100


Since pituitary adenylate cyclase-activating polypeptide (PACAP) was shown to partially mediate nonadrenergic, noncholinergic (NANC) relaxation of longitudinal muscle of the proximal colon of ICR mice, we further studied the receptor subtype activated by PACAP by using a mutant mouse whose PAC1 receptors are markedly reduced. In wild-type mice, the PACAP-mediated component of NANC relaxation was 33%, but it was absent in the mutant mice. The potency of exogenous PACAP in inducing relaxation in the mutant mice was one hundredth of that in wild-type mice. VPAC1 and VPAC2 receptors were not suggested to have any role in the relaxation. These results suggest that PACAP mediates NANC relaxation of longitudinal muscle of mouse proximal colon via PAC1 receptors.

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© The Japanese Pharmacological Society 2002
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