Abstract
Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph1-ALL) is recognized as a chemotherapy-resistant hematological malignancy in children. We report eight cases of patients with Phi-ALL who underwent bone marrow transplantation (BMT) in a single institution. The patients included four boys and four girls ranging in age 3-15 years. Transplants were conducted from July 1986 to May 1994. Transplant types included one case of syngeneic transplant, two cases of autologous transplant and five cases of allogeneic transplant. The donors included HLA identical siblings in three cases, an HLA-B locus mismatched mother and a matched unrelated donor. The transplants were conducted at first remission (four cases), second remission (three cases) and relapse (one case). Engraftment was obtained in seven cases, and second transplants were done from the same donor for the single relapse patient and another patient in which rejection was observed. In the four cases of allogeneic transplants with engraftment, two cases of grade II-III acute graft versus host disease (GVHD) were observed. Three of the patients were alive and in remission 35-79 months after transplantation and five patients died of either relapse (two cases) or veno-occlusive disease (VOD) (three cases) 0-19 months after transplantation.
