A Case of Acute Lymphoblastic Leukemia Showing Markedly Increased Uptake in the Bone without Uptake in the Liver by⁶⁷Ga Scintigraphy

Abstract

A 5-year-old girl with acute lymphoblastic leukemia showed increased uptake in the bone and decreased uptake in the liver by⁶⁷Ga scintigraphy. Subsequently, the bone uptake decreased after beginning remission induction treatment. It is believed that⁶⁷Ga-citrate was taken by the leukemic cells through the transferrin receptors and distributed to the systemic bone marrow.⁶⁷Ga scintigraphy is widely used for malignancies such as malignant lymphoma, however, its significance for leukemia has not been evaluated.⁶⁷Ga scintigraphy may be useful to evaluate the extent of bone marrow invasion of leukemic cells and response to treatment.