Abstract
In order to determine the prognostic factor of aplastic anemia (AA) patients, we examined the number of bone marrow colony-forming units-erythroid (CFU-E), serum erythropoietin (Epo), interleukin-2 (IL-2) production and interferon-γ (IFN-γ) production in AA patients. 1. The number of CFU-E colonies was lower in patients with severe AA than in patients with mild or moderate AA. The recovery of CFU-E colonies under treatment was a favorable sign in the course of illness. 2. The serum Epo level depended more on the condition of the patients at the time of examination than the severity at onset. 3. Serum IL-2 production increased in transfusion dependent cases. 4. Serum IFN-y production did not decrease in the cases of AA patients as compared to the controls.
