Abstract
The Bone Marrow Transplantation Committee of the Society has conducted anannual registry of bone marrow transplantation in children in Japan since 1983. As of June 30, 1996, 3, 221patients had received stem-cell transplantation, an increase of 535 patients from the 1995 registry, andwere registered from 125 institutions. In this paper, the results of the main diseases were analyzed to determine whether or not the actuarial disease-free survival (DFS) rates of allogeneic bone marrow transplantation were different before and after 7/1/1990 in addition to annual analysis. There were no significant differences in the patients with acute lymphoblastic leukemia or acute myeloid leukemia who received HLA-matched sibling bone marrow at the 1st complete remission (CR) or 2nd CR between the two periods. The DFS rate of patients transplanted at the 3rd CR after 7/1/1990 was better than that of patients transplanted before 7/1/1990 (45.6 ± 14.1% vs 14.3 ± 13.0%, p < 0.01). There were no significant differences in adult-type chronic myelocytic leukemia patients who received HLA-matched sibling bone marrow at the 1st chronic phase, although there was a tendency of better results for patients who were preconditioned with total body irradiation regimens in both of the periods. The DFS rates of patients with severe aplastic anemia who received HLA-matched sibling bone marrow (110 cases) or unrelated bone marrow (19 cases) after 7/1/1990 were 89.2 ± 6.2% and 68.4+ 20.9%, respectively. Unrelated bone marrow transplantation from “donor bank” donors was performed on 214 children with an overall DFS rate of 49.2 8.6%. Allogeneic cord blood stem-cell transplantation was done on 8 children, and allogeneic PBSCT was performed on 27 children.
