Abstract
We report a case involving a 4-year-old boy with osteosarcoma. He failed to respond to chemotherapy according to the Rosen T-12 protocol and to surgical operations, and relapsed. He had multi-relapse in the lung and brain after one year. Therefore he underwent mega-dose chemotherapy followed by 8 autologous bone marrow transplantations. Multidisciplinary treatment included 6 surgeries, radiotherapy of a total 30 Gy and mega-dose chemotherapy with autologous BMT 8 times. The patient obtained disease-free survival for one and a half years, though he later died because of mandibula relapse. Mega-dose chemotherapy followed by plural autologous stem cell transplantation for advanced osteosarcoma will be useful to get complete remission in the future.
