Abstract
Two cases with acute leukemia secondary to the chemotherapy for non-Hodgkin's lymphoma (NHL) are reported. One case involved an 11-year-old girl. She has suffered from acute monoblastic leukemia (M5a) six years and seven months after the diagnosis of NHL. The other case is a 5-year-old boy. He has suffered from acute lymphoblastic leukemia seven years and four months from the diagnosis of NHL. It is noted that bothpatients have received LSA2-L2 protocol, both had a period of MDS (myelodysplastic syndrome) that developed into acute leukemia, and both had the same chromosomal abnormality of -7. It is suggested that the leukemia of these cases is associated with alkylating agents that were given for treating NHL. Secondary leukemia associated with etoposide is well described, but few leukemia cases secondary to alkylating agents have been reported in Japan.
