Abstract
We reported three young girls with localized Langerhans cell histiocytosis of ilium, who were accompanied by gait disturbance. Plain radiograph showed the lytic defect of ilium, and computed tomography scans revealed mass lesion with bone destruction. They were diagnosed as eosinophilic granuloma by open biopsy. Their clinical courses followed the treatment well with direct injection of steroids into bone lesion. In Patient 3 with rib lesion other than iliac lesion at presentation, the osteolytic lesion of both rib and ileum disappeared within 2 months after only a single injection of methylprednisolone into the ilium. This suggested that the direct-injection therapy of steroids may be effective in cases with multiple bone lesions. Because the direct injection of steroids is relatively noninvasive and easy without severe complications, it might be considered as a first-line therapy for the localized Langerhans cell histiocytosis of bone.
