Abstract
L-Asparaginase (ASP) is a useful antileukemic agent, but has been believed to be very toxic. Common toxic reactions are associated with hypersensitivity and inhibition of hepatic protein synthesis. Under the current method of administration, most toxic reactions are tolerable and avoidable. However, we must be alert to rare serious complications such as anaphylaxy shock, acute pancreatitis, and thrombotic complication of the central nervous system. For prophylaxis and early diagnosis, very close observation of the clinical symptoms are necessary during or after the treatment with ASP. Laboratory tests such as plasma antithrombin III and serum amylase may be useful for monitoring those complications.
