Abstract
Eighty-eight patients with ITP in children, treated in our center, were divided into acute and chronic types, and their clinical findings and results of clinical laboratory tests at the onset were retrospectively compared between the acute and chronic types. Furthermore, the prognosis of chronic types was examined. No difference was found between acute and chronic types in the age of onset, sex, presence of preceding infection, initial symptoms, treatment, platelet counts, PA-IgG levels, presence of antinuclear antibody, and/or LE test. Lupus anticoagulant (LA) was significantly more frequent in the chronic type than in the acute type and was considered one factor for poor prognosis. With respect to the prognosis of chronic types, the rates of spontaneous remission at 1, 2, and 8 years were 9, 40, and 60%, respectively. Patients who had no remission 6 years or more after the onset, often had a complication of abnormal immunity such as collagen disease and antiphospholipid antibody syndrome.
