Abstract
The Hematopoietic Stem-Cell Transplantation Committee (previously the Bone Marrow Transplantation Committee) of the Society has conducted an annual registry of hematopoietic stem-cell transplantation in children in Japan since 1983 and published the results until 1997. In 1998, the data of children and adults were combined by using several utilities, and patients from 1991 to 1998 were analyzed and reported in JSHCT monograph, vol. 2. However, since the data of children are not enough in the monograph, more data for children transplanted from 1990 to 1998 are reported in this paper. The DFS rates of patients with severe aplastic anemia who received allogeneic bone marrow transplants are 85.3+7.1% (mean, 95% CI) from I-ILA-matched sibling donors and 72.0+13.1% for BMT from HLA-matched unrelated donors. The DFS rates of patients with AML who underwent transplants in the first CR are 70.5+7.2% for HLA-matched sibling donors, 72.5±10.3% for ABMT and 53.4±11.7% for AutoPBSCT. Statistically significant differences are found between the DFS rate of BMT from HLA-matched sibling donors and from AutoPBSCT (p <0.01) and between the DFS rate of ABMT and that of AutoPBSCT (p <0.05). The DFS rates of patients with ALL who underwent transplants in the first CR are 65.1+11.1% for HLA-matched sibling donors, 52.4+22.8% for ABMT, and 65.9+8.8% for AutoPBSCT. No statistically difference is found among them. The number of transplants reported were 594 for BMT from unrelated donors, 86 for cord blood stem-cell transplantation, and 79 for allogeneic PBSCT.
