Abstract
We report two patients with aplastic anemia who developed hepatocellular adenoma after long-term therapy with oxymetholone. Patient 1. A 20-year-old male was diagnosed with severe aplastic anemia at 13 years of age. Six years after the start of oxymetholone therapy (total dose 125 g), the patient developed multiple hepatic tumors. These tumors regressed after cessation of oxymetholone, but he died of sepsis. Tumors were confirmed to be hepatocellular adenoma by autopsy. Patient 2. A 22-year-old male was found to be anemic at age 7 and diagnosed as having aplastic anemia. He underwent oxymetholone therapy (226 g) for 14 years. A liver biopsy from the left hepatic lobe was performed. The mass was suspected to be hepatocellular adenoma. A tendency for it to regress was noted after the withdrawal of oxymetholone. The patient underwent bone marrow transplantation from his older brother, and his hematological data recovered. The main cause of death from hepatic tumor occurrence in these cases was sepsis, bleeding tendency, and rupture of the tumors. A follow-up of hepatic tumor by echogram and treatment of the original disorder after the cessation of drugs are important in cases of this kind.
