Abstract
We report here two cases of childhood Sjögren's syndrome (SjS), who were complicated with aseptic meningitis and hemophagocytic syndrome. Sialography and auto-antibody studies (positive SS-A and SS-B) had indicated SjS. An 11-year-old boy was admitted to our hospital for headache and fever. Laboratory findings revealed leukopenia, thrombocytopenia, increased serum concentrations of ferritin and TNF-α, and elevated leukocyte count in cerebrospinal fluid (CSF). Two years after diagnosis he was diagnosed as having aseptic meningitis again. An 8-year-old girl was admitted to our hospital for headache and fever. Laboratory findings revealed leukopenia, thrombocytopenia, increased serum concentrations of ferritin and transaminase, and elevated leukocyte (containing of macrophage) count in CSF. A half year after diagnosis she was suffering from headaches again. We report these cases because aseptic meningitis and hemophagocytic syndrome are uncommon complications in childhood SjS.
