2002 Volume 16 Issue 5 Pages 308-311
We report a 13-year-old boy with dic (9 ; 12) -positive acute lymphoblastic leukemia (ALL) who had a 2-week history of fever and jaundice. Physical examination demonstrated an enlargement of the liver and the spleen ; peripheral blood tests showed a white blood cell count of 1, 600/μl with 12%blasts and a platelet count of 6.9×104/μl. Serum biochemical tests indicated abnormal findings for AST (630 U/l), ALT (619U/l), and direct bilirubin (3.2mg/dl). Leukemic cells showed morphological characteristics of FAB L1 and were positive for CD 10, CD 19, and CD20 on surface marker analysis. Cytogenetic analysis demonstrated a karyotype of 45, XY, inv (1) (p22q44), der (12), and dic (9 ; 12) (p11 ; p12). Our patient showed good response to chemotherapy, as much like that reported in previous cases. We could find no reports of Japanese patients complicated by jaundice.
