Abstract
We report two patients with thrombocytopenia induced by carbamazepine (CBZ). They were diagnosed as having epilepsy and treated with CBZ. Case 1, a 12-year-old girl, was admitted because of purpura on the legs and thrombocytopenia (30×103/μl) 15 days after the initiation of CBZ treatment. Case 2, a12-year-old boy, was admitted because of purpura and thrombocytopenia (10×103/μl) 13 days after the beginning of CBZ treatment. We studied the circulating levels of thrombopoietin (TPO) and interleukin-6 (IL-6). TPO values during the acute phase were higher than those during the recovery phase. Especially, the TPO value for Case 1 during the acute phase was higher than that in controls. IL-6 value during the acute phase was higher than that during the recovery phase for Case 2. There was no significant, fluctuation in Case 1. Further studies are required regarding the clinical relevance of TPO in drug-induced thrombocytopenia.
