Abstract
We report the case of a 2-year-old boy with acute lymphoblastic leukemia who presented Charcot-Marie-Tooth (CMT) disease following the administration of vincristine (VCR) for acute lymphoblastic leukemia. After the patient received a total dose of 8 mg/m2 of VCR, he demonstrated marked muscle weakness, distal muscle atrophy in the arms and legs, pes cavus, foot drops, claw hand, tremor, and diminished deep tendon reflex, suggesting the presence of CMT disease. By genetic analysis, he was shown to have duplication of the PMP22 gene, and was diagnosed as CMT type 1A. Although his mother and maternal grandmother were asymptomatic, they were also diagnosed as CMT type 1A. He has been on complete remission by chemotherapy without VCR. Care should be taken to pay attention to the possibility of masked CMT disease when administering VCR.
