Abstract
We report a seven-month old boy with N-myc amplified neuroblastoma (NB) detected by mass screening (MS). He was pointed out by the high levels of urinary VMA and HVA by MS and diagnosed as having stage 1 NB after detailed examinations. After complete excision of the tumor, we planned to treat with chemotherapy because N-myc amplification was over 40 copies which indicated poor prognosis. But we followed him without any treatment by reason of parental refusal. Four months after discharge, right side exophthalmus, high levels of urinary VMA and HVA, and bone marrow metastasis were recognized. Recurrence of NB was diagnosed. We started chemotherapy and stem cell transplantation (SCT) is planned. There are few cases of N-myc amplified NB detected by MS. In such cases, intensive treatment including SCT should be considered.
