Abstract
Immunoglobulin-like receptors (IgLR), which have immunoglobulin (Ig) -like domains in their extracellular portions, are of two types : Activating type receptors which activate cellular signaling, and inhibitory type receptors which repress cellular activation. Analysis of mice lacking Fc receptors (FcRs), one of the IgLRs, has revealed their essential roles in the regulation of various immune responses. Recent reports suggest that novel IgLR family receptors as well as FcRs are involved in the development of various human diseases. This review provides an overview of IgLR-mediated immune regulation, highlighting the implication of FcRs in the development of autoimmune disease.
