1988 Volume 2 Issue 4 Pages 395-399
This report describes a 14-year-old-boy with hemophilia B. He had been treated with a large amount of Factor IX concentrate since 6 months of age and showed a very high level of Factor IX inhibitor (185 Bethesda U/ml). He was admitted because of intracranial bleeding. We treated him successfully with “bypassing therapy” using activated and non-activated Prothrombin Complex Concentrates (Autoplex® and Proplex® ST, respectively). Based on the data from this patient and a few cases reported previously, clinical courses and therapeutic protocols for the hemophilic patients with high Factor IX inhibitor were discussed.