1988 Volume 2 Issue 4 Pages 434-438
We report a 3-year-old boy having acute non-lymphocytic leukemia (ANLL) with both granuloid and monocytic features in the esterase activity. He presented with mild anemia, bleeding tendency, hepatomegaly and lymphadenopathy. The white blood cell count was 17, 300/μl with 34% of leukemia cells. The bone marrow contained 96% of leukemic cells which had promyelocytoid morphology. The cells were strongly positive for peroxidase. They were positive for both naphthol-AS-D-chloroacetate and α-naphthyl butyrate esterases, and the latter esterase activity was inhibited by NaF. The chromosome analysis revealed an abnormal 45, X, -Y, t (1p-; 14q+), 9q+, 12q- pattern. The leukemia appears to be an M3 type of ANLL with unusual cytological features.
