Succesful Treatment with Unrelated Donor Bone Marrow Transplantation in a Young Girl with t (6;9) (p23;q34) Positive Acute Myeloid Leukemia

Abstract

A 6-year-old girl, who was diagnosed as acute myeloid leukemia (AML-M2) with t (6;9) (p23;q24) and with expression of the DAK-CAN fusion protein, treated on the CCLSG AML9805 protocol. A complete remission (CR) was achieved after induction and salvage chemotherapy. She underwent allogenic bone marrow transplantation (BMT) from an unrelated donor. The pre-conditioning regimen included busulfan and melphalan. The clinical course was uneventful, and hematological recovery occurred rapidly. She was in CR with negative PCR for DEK-CAN and survived for five years. It may be suggested that achieving DEK-CAN negativity after BMT in the first CR leads to a good prognosis for t (6;9) -AML.