1989 Volume 3 Issue 4 Pages 351-355
We investigated the prognosis of 46 children with acute lymphoblastic leukemia who relapsed during or following the initial treatment program of Nagoya Children's Hematology/Oncology Study Group (protocol 7804 and 8104). Overall survival and disease-free survival rates were 24% and 19% at five years, respectively. The prognosis of 34 children in bone marrow relapse was extremely poor, regardless of any other prognostic factors. With regard to the prognosis of 9 children in meningeal relapse, initial remission duration longer than one year was a good prognostic factor after relapse. More intensive treatment including bone marrow transplantation should be employed in patients with bone marrow relapse.
