Abstract
A 14-year-old boy with acute nonlymphocytic leukemia (ANLL) having t (7;11) (p15 ; p15) is reported. The patient had hepatomegaly and right knee joint swelling, and showed WBC 117, 500/μl (blast 47%, Auer rod positive), Hb 8.5g/dl, and platelet count 12.8 × 104/μl. The bone marrow findings, NCC 40 × 104/μl (blast 36.5%), were compatible with M2 by the definition of FAB (French-American-British). A chromosomal analysis of both his peripheral blood and bone marrow before treatment revealed t (7; 11) (p15 ; p15). The patient received systemic chemotherapy including high-dose Ara-C (cytosine arabinoside), attained a complete remission 2 months later, and was in remission for 8 months. Subsequently he relapsed and died of respiratory failure. He had been alive for 13 months after the initiation of induction therapy. A survey of the literature, including this case, demonstrated a total of 19 leukemia cases with a reciprocal translocation t (7p-; 11p+).
