Abstract
A 14-year-old boy with a 4-month history of fever and arthralgia was admitted to D.U.H. Osteolytic degeneration of the pelvis and cranial bone was found on X-ray examination. Collapse of the 7th-8th, 11th thoracic vertebrae and the 4th lumbar vertebra was also noted. The lymphnode biopsy from the right inguinal region revealed infiltration of giant tumor cells accompanied with lymphocytosis. By surface marker analysis, the tumor cells were positive for CD30 (Ki-1), epithelial membrane antigen, HLA-DR and leukocyte common antigen. The patient was diagnosed as having Ki-1-positive malignant lymphoma based on the above clinical and laboratory findings, and was treated with chemotherapy according to TCCSG T8801-protocol in addition to radiation therapy for the relief of arthralgia. He has been free from complaints for eight months.
