Transient Psychotic Reaction and SIADH during Preconditioning Therapy in Allogeneic Bone Marrow Transplantation

Abstract

A 13-year-old girl with chronic myelogenous leukemia developed hyponatremia and psychotic reaction by SIADH during preconditioning regimen of allogeneic marrow transplantation. It was suggested that the most likely cause of this disease was the high-dose cyclophosphamide therapy and emotional stress in a laminar air flow unit. Whenever the high-dose cyclophosphamide therapy is used as preconditioning therapy in an older child, we should constantly pay attention to the occurrence of SIADH and try to relieve the patient's emotional stress. In our case, allowing her mother to stay in the clean unit effectively relieved the patient's emotional stress.