Abstract
We report two cases of Down's syndrome with acute megakaryoblastic leukemia, who remain in continuous complete remission following the cessation of therapy. Patient 1 was a 25-month-old girl and Patient 2 was a 21-month-old boy. Blasts in both patients were positive for monoclonal antibodies recognizing platelet associated antigen (CDw41 and CDw42) and for platelet peroxidase by analysis with electron microscopy. Chemotherapy regimen in Patient 1 consisted of cytocine arabinoside 100 mg/m2 for 7 days and daunomycin 30 mg/m2 for 2 days. In addition, VP-16 150 mg/m2 was given to Patient 2 for 3 days. After being treated with eight courses of the chemotherapy for eight months, both patients have been given follow-up examinations without chemotherapy. Complete remissions were obtained after two courses of chemotherapy in Patient 1, and after three courses in Patient 2. They have remained in complete remission for 36 months (Patient 1) and 17 months (Patient 2) since the cessation of therapy.
