Two Cases of Aplastic Anemia Who Acquired Complete and Partial Remission by rhG-CSF Therapy

Abstract

Two cases of untreated aplastic anemia (severe type) in childhood were treated by recombinant human granulocyte colony stimulating factor (rhG-CSF). In response to rhG-CSF, the first case suspectedly associated with infection showed increase of neutrophils followed by increase of erythrocytes and platelets within two weeks. The other idiopathic case also showed partial response. Furthermore, during rhG-CSF therapy, serum immunoglobulin levels were doubled and T cell subsets were altered in both cases. rhG-CSF appeared to influence the immune system in vivo and to be effective for a certain group of patients with aplastic anemia.