Abstract
A 5-year-old boy presented with a history of left postauricular mass (20 mm × 17 mm). The tumor was an enlarged lymph node and was completely resected. Histological diagnosis was Non-Hodgkin's lymphoma, lymphoblastic type, by Japanese Lymphoma Study Group class. An immunophenotyping analysis of frozen tissue sections revealed that tumor cells showed HLA-DR+, CD 10+, CD 19+, CD20- and CD34- indicating that they classified to pre-B-cell phenotype. Bone marrow contained 22.3% atypical lymphocytes with basophilic nuclei, dusky chromatin, and scanty cytoplasm, but not convoluted nuclei. Immunophenotyping of marrow mononuclear cells revealed that about 30% of cells had the same surface markers as tumor cells of the resected lymph node. He was treated with chemotherapy designed for intensive high-risk acute lymphoblastic leukemia (CCLSG 874), and has now been in complete remission for 6 months after induction chemotherapy. Previous reports with pre-B-cell lymphoblastic lymphoma including our case were also reviewed.
