1992 Volume 6 Issue 5 Pages 455-459
Of children with Burkitt's lymphoma treated at our clinic for the past five years, we report here the therapeutic results of those treated in accordance with a modified NCI 77-04 protocol of Magrath et al. They were seven boys and two girls, age ranged 2 to 14 years. The primary site was intestine in five children, neck in two and pharynx in two. Staging at the first examination was Stage I in two cases, Stage II in three, Stage III in three and Stage IV in one. Treatment comprised complete resection by surgery in four cases, partial resection in three and biopsy only in two. Post operatively, treatment in accordance with the protocol was instituted, and radiotherapy was concurrently used in five children. The protocol was completely accomplished in eight of nine children, and all are still alive (2 yrs 10 months-6 yrs 3 months). Recurrence of the tumor was detected in two cases, but in one case remission was achieved by reinduction therapy. The other case in which remission was not attained was in Stage IV ; this child died from infiltration of multiple organs, including the central nervous system. Stomatitis occurred frequently as an adverse reaction of this therapy, but this was reversible. The therapy may thus be considered a modality as it showed and maintained a high rate of remission for Burkitt's lymphoma.
