1992 Volume 6 Issue 5 Pages 515-520
We described a case of nephrotic syndrome (NS) associated with Hodgkin's disease (HD) in a 4-year-old boy. He was admitted because of left cervical lymphadenopathy and generalized edema. Nodular sclerosing type of HD was diagnosed by the cervical lymphnode biopsy. The clinical staging of HD was stage IA. Although his renal function was normal (Ccr 98.5 ml/min/1.73 m2), he had NS (serum T.P. 4.4 g/dl; serum Alb. 1.8 g/d1; serum T. cho. 331 mg/di; urine protein8.6 g/day). The renal biopsy showed minor glomerular abnormalities. The clinical manifestation of NS improved after lymphnode biopsy, but relapsed soon. Proteinuria disappeared within several days with prednisolone treatment (60 mg/m2) and irradiation to the involved field. HD complicating NS has been classically documented, but their association is particularly rare in childhood. This case showed normal OKT 4/8 ratio (1.91) and normal lymphocyte stimulation test with lectin, although the mechanism of the association is interpreted to be due to lymphocyte dysfunction of HD.
