1993 Volume 7 Issue 5 Pages 457-461
Eight children undergoing allogeneic BMT for acute leukemia (one with AMoL, seven with ALL) were conditioned with a combination of CY-TBI or BuCy2 plus high-dose Ara-C and high-dose VP-16. Status at transplantation was as follows : three in first CR, two in second CR, one in third CR, two in relapse. One patient transplanted in early relapse received second BMT from same donor. Major regimen-related toxicities were oral mucositis and gastrointestinal tract symptoms such as nausea, vomiting and diarrhea.Acute GVHD greater than grade II was seen in two patients and one died with grade IV GVHD and cytomegalovirus pneumonitis. The incidence of chronic GVHD in seven patients who survived more than 100 days after BMT was 0%. Two children, one transplanted in 3rd CR and another in relapse, experienced relapse of leukemia and both died 48 and 57 weeks after BMT. Now five patients survive without disease 83+ -110+ weeks after BMT. Conditioning regimen which includes high-dose Ara-C and high-dose VP-16 for allogeneic bone marrow transplantation is well tolerated and effective for acute leukemia of children.
