Abstract
We examined the combined effects of granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) on CFU-GM colony and recovery of granulocyte count after chemotherapy of leukemia. Admixture of G-CSF and M-CSF increased more CFU-GM colonies than admixture of G-CSF or M-CSF, and the numbers of CFU-GM stimulated by G-CSF and M-CSF were more than the sum of CFU-GM stimulated by G-CSF or M-CSF alone. In administration of G-CSF and M-CSF after chemotherapy of leukemia, there were earlier recoveries of granulocyte count than in administration of G-CSF or M-CSF. These data suggested that G-CSF and M-CSF may be administered simultaneously when prompt recovery of granulocyte count is required.
