Abstract
An 8-year-old girl with acute lymphoblastic leukemia (high risk) was complicated with Candidia liver abscess during consolidation therapy. Amphotericin B (AMPH) was administrated intravenously (with a dose up to 0.8 mg/kg/day) in combination with intravenous fluconazole, but it was ineffective. Oral administration of high-dose AMPH (12, 000 mg/day) also failed to normalize C-reactive protein (CRP) although her fever resolved to normal. And then AMPH was administrated through a catheter inserted into the portal vein after laparotomy. In about 2 weeks after institution of this therapy, CRP became negative, and the multiple hepatic mass lesions on CT scans disappeared within 2 months. The patient received bone marrow transplantation (BMT) at the age of 9 years 9 months old. She remains disease free 15 months after BMT.
